Efficiency of Fe3O4@ZIF-8 for the removal of Doxorubicin from aqueous solutions: equilibrium, kinetics and thermodynamic studies.

Due to inadequate pharmaceutical wastewater treatment, anticancer contaminants from the pharmaceutical industry frequently end up in the aquatic environment where they endanger aquatic life and humans. As a result, the appropriate treatment of wastewater that contains anticancer agents is crucial for pollution prevention. The purpose of this work is to assess the effectiveness of a Fe3O4@ZIF-8 nanocomposite as an adsorbent to remove of the chemotherapeutic drugs doxorubicin (DOX) from aqueous solution. SEM, XRD, BET, FT-IR, Zeta potential, and point of zero charge analysis were used to study the surface and structural characteristics of the Fe3O4@ZIF-8 nanocomposite. Via the proposed treatment, 804.84 mg/g elimination was successful under the following circumstances: pH = 6; Fe3O4@ZIF-8 dose = 0.02 g/25 mL; DOX concentration = 1.22x10-3 mol; adsorption time = 100 min; and shaking speed = 200 rpm. A investigation of isotherms shown that the Langmuir equation and experimental data suited each other quite well. The adsorption of DOX on Fe3O4@ZIF-8 was endothermic and spontaneous, in accordance with thermodynamic properties. Furthermore, the elimination of DOX was enhanced by the rise in solution temperature. The kinetic analysis revealed that the pseudo-second order was fitted by the model. The suggested adsorption method could recycle Fe3O4@ZIF-8 nanocomposite six times, with a modest reduction in its ability for adsorption. For all XRD reflection peaks, physical characteristics including strain rates were computed and the dislocation of was 4.7 × 10-6. Investigate the activity of the DOX towards COVID-19, breast and prostate cancer using molecular docking.